• Histoacryl® topical skin adhesive should be used only on wounds that have been thoroughly cleaned, debrided and have easily apposed wound edges.

  • Histoacryl® generates a small amount of heat during polymerization and should not be applied to tissues that may be affected by such heat.

  • Histoacryl® should always be applied very sparingly, either as minute drops or as a very thin film along the edges of the wound.  Heavy application may cause thermal damage to tissues, and delayed healing may result.

  • Histoacryl® should not be applied to wet wounds.  Excess moisture, such as water or alcohol, may accelerate polymerization, resulting in the generation of excess heat.

  • Use of the Histoacryl® may result in localized sensitization or irritation reactions.

  • Application and/or migration (leak) of either version of the product below the surface of the skin will impair the healing process by forming a barrier between tissue edges.

  • Histoacryl® Blue migration (leak) below the epidermal surface may result in “tattooing” of the underlying tissue.

  • Histoacryl® will readily adhere to most substrates.  Care should be taken to avoid unwanted contact with the adhesive during polymerization.  Polymerized adhesive can be removed from metal instruments with acetone.  Accidental bonding of materials other than tissues may be reversed by peeling apart the adhered surfaces with the aid of warm soapy water, petroleum gel, saline solution, or 5% solution of sodium bicarbonate.

  • Accidental bonding of unwanted skin may occur.  Do not pull apart skin.  Instead, accidental bonding of unintended areas of skin of the body can be corrected with the use of acetone or by soaking in warm water until the skin may be separated.

Copyright 2005 TissueSeal, LLC. All images copyright © by respective artists and photographers. All rights reserved. All text and images on this site can not be used or reproduced without the expressed written consent of TissueSeal, LLC. Histoacryl® is a trademark of B. Braun Corporation.