• Histoacryl® topical skin adhesive is not to be applied below the surface of the skin.  The liquid adhesive will react exothermically with tissue; the polymerized adhesive is not absorbed by any tissues and may elicit a foreign body reaction.

  • Histoacryl® is not to be applied to any internal organs, blood vessels, nerve tissue, mucosal surfaces or mucocutaneous junctions, areas with dense natural hair, or within the conjunctival sac of the eye.

  • Histoacryl® is not to be applied to the surface of the eye.  If the eyelids are accidentally bonded closed, release eyelashes with warm water by covering with a wet pad.  The adhesive will bond to eye protein and will cause periods of weeping which will help to debond the adhesive.  Keep the eye covered until debonding is complete – usually within 1 to 3 days.  Do not force the eye open.

  • Histoacryl® is not to be applied to wounds subject to high skin tension, or on areas of increased skin tension such as the elbows, knees, or knuckles.  Histoacryl® is not to be used in areas of skin excision.

  • Histoacryl® is not to be applied to wounds that show evidence of infection, gangrene or wounds of decubitus etiology.

  • Histoacryl® is not to be used on patients with known preoperative systemic infections, uncontrolled diabetes, or diseases or conditions that are known to interfere with the wound healing process.

  • Histoacryl® is not to be used on patients with a known hypersensitivity to cyanoacrylate, formaldehyde, or the dye D&C Violet #2.

Copyright 2005 TissueSeal, LLC. All images copyright © by respective artists and photographers. All rights reserved. All text and images on this site can not be used or reproduced without the expressed written consent of TissueSeal, LLC. Histoacryl® is a trademark of B. Braun Corporation.

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